Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells as a Novel Stem Cell Source for Regenerative Medicine Applications

    December 2017 in “ Frontiers in Cell and Developmental Biology ”
    Marco Tatullo, Bruna Codispoti, Andrea Pacifici, Francesca Palmieri, Massimo Marrelli, L Pacifici, Francesco Paduano
    Studysummary This review discusses the potential of mesenchymal stem cells from human periapical cysts for regenerative medicine, highlighting their easy accessibility and valuable regenerative properties, but reports no new clinical findings. Our plain-language summary of this paper — not a Tressless recommendation.
    The document discussed the potential use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel source for regenerative medicine. These stem cells, isolated from periapical cysts, showed extensive proliferative potential, self-renewal capacity, and the ability to differentiate into osteogenic, adipogenic, and chondrogenic lineages. They had a higher osteogenic potential compared to dental pulp stem cells (DPSCs), which were more inclined towards dentinogenesis. The study highlighted the promising role of hPCy-MSCs in tissue regeneration, particularly in bone formation, and suggested their potential application in regenerative therapies. However, it noted that most findings were based on in vitro experiments, and further in vivo research was necessary to confirm their regenerative potential.
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