Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells as a Novel Stem Cell Source for Regenerative Medicine Applications

The document discussed the potential use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel source for regenerative medicine. These stem cells, isolated from periapical cysts, showed extensive proliferative potential, self-renewal capacity, and the ability to differentiate into osteogenic, adipogenic, and chondrogenic lineages. They had a higher osteogenic potential compared to dental pulp stem cells (DPSCs), which were more inclined towards dentinogenesis. The study highlighted the promising role of hPCy-MSCs in tissue regeneration, particularly in bone formation, and suggested their potential application in regenerative therapies. However, it noted that most findings were based on in vitro experiments, and further in vivo research was necessary to confirm their regenerative potential.