SUN-439 Hypothalamic-Pituitary-Adrenal Axis Disruption from Unregulated Glucocorticoid Use: A Case Series

    October 2025 in “ Journal of the Endocrine Society ”
    Swecha Prakash Potharaj, ebunoluwa Oshinuga, Zygy Roe-Žurž, Aman Rajpal, Rahul Sharma, N Doshi
    TLDR Unregulated glucocorticoid use can disrupt hormone balance and cause serious health issues.
    The document presents a case series of four patients who developed iatrogenic hypothalamic-pituitary-adrenal (HPA) axis disruption due to the use of over-the-counter (OTC) glucocorticoid-containing agents marketed as joint pain medications or "vitamin shots." These cases highlight the risk of iatrogenic Cushing syndrome and subsequent adrenal insufficiency, particularly among immigrant populations using medications from other countries. The study emphasizes the importance of thorough medication reconciliation by healthcare providers to prevent exposure to hidden glucocorticoids and associated health complications.
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