[Hormonal interaction and hair growth].

The document discussed androgenetic alopecia (AGA), the most common form of hair loss in men and women, characterized by a pattern of hair loss in genetically predisposed individuals. It was identified as a dihydrotestosterone (DHT)-dependent process involving the miniaturization of hair follicles. Although the genetic factors were unknown, the hormonal effects on hair growth were better understood, with local androgen metabolism playing a crucial role. The dermal papilla was highlighted for its role in regulating hair follicle growth through steroidogenic isoenzymes, which could explain differences in androgen sensitivity. These enzymes were considered potential targets for treating AGA or hirsutism.