August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that excessive consumption of nutmeg, ginger, cloves, and mixed spices led to significant liver damage and other health issues in laboratory mice.
May 2021 in “Indian journal of forensic medicine and toxicology” This study found that excessive consumption of cloves in mice caused toxic changes in the liver, including structural damage and cell death, but concluded these effects are not considered dangerous.
13 citations
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March 1999 in “Biochemical Journal” In this study, transgenic mice overexpressing the SSAT gene were highly sensitive to polyamine analogues, leading to severe liver changes and high mortality rates after treatment.
43 citations
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February 1999 in “Biochemical Journal” This study found that transgenic mice overexpressing the SSAT gene under a metallothionein promoter suffered delayed hair loss and were highly sensitive to polyamine analogues, which led to significant liver changes and mortality.
December 2023 in “Journal of nutritional science and vitaminology” This study in mice found that a zinc-deficient diet suppressed body weight gain and increased kidney and cecum tissue weight without decreasing serum alkaline phosphatase activity. Additionally, zinc deficiency caused alopecia and intestinal changes in C57BL/6J mice, potentially affecting nutritional status.
