High-Dose Oral Minoxidil for the Treatment of Androgenetic Alopecia

    May 2025 in “ Actas Dermo-Sifiliográficas ”
    Óscar Muñoz Moreno-Arrones, Ángela Hermosa‐Gelbard, David Saceda‐Corralo … Sergio Vañó‐Galván
    Studysummary This study evaluated high-dose oral minoxidil treatment in 57 patients with androgenetic alopecia and found it improved hair density by 10-30% in most cases, but 24.6% experienced adverse effects like hypertrichosis and tachycardia, indicating further research is needed to optimize safety and efficacy.
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    Research cited in this study 7

    1. Oral Minoxidil for Late Alopecia in Cancer Survivors Breast Cancer Research and Treatment · 2024
    2. Prospective Evaluation of Blood Pressure, Heart Rate, and Side Effects in Hypertensive Patients Using Low-Dose Oral Minoxidil for Hair Loss Journal of the American Academy of Dermatology · 2024
    3. Oral Minoxidil 7.5 mg for Hair Loss Increases Heart Rate with No Change in Blood Pressure in 24-Hour Holter and 24-Hour Ambulatory Blood Pressure Monitoring Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2024
    4. Clinical Efficacy and Safety of Low-Dose Oral Minoxidil Versus Topical Solution in the Improvement of Androgenetic Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2023
    5. Low-Dose Oral Minoxidil for Androgenetic Alopecia Is Not Associated With Clinically Significant Blood-Pressure Changes: A Retrospective Study Journal of The American Academy of Dermatology · 2023
    6. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2023
    7. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021

    Related research 9

    1. Contact Dermatitis Caused by Topical Minoxidil: Allergy or Just Irritation Acta Dermato Venereologica · 2025
    2. Continued Year-On-Year Improvement in Hair Density With Systemic Minoxidil in Women With Female Pattern Hair Loss: A Case Series Journal of the American Academy of Dermatology · 2025
    3. Role Of Oral Minoxidil In The Treatment Of Androgenetic Alopecia Cosmoderma · 2024
    4. A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss Clinical and Experimental Dermatology · 2018
    5. 5% Minoxidil: Treatment for Female Pattern Hair Loss PubMed · 2015
    6. Androgenetic Alopecia in Adolescents PubMed · 2003
    7. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    8. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    9. The Use of Minoxidil to Prevent Alopecia During Chemotherapy for Gynecologic Malignancies PubMed · 1991