High-Dose Mizoribine Treatment for Adolescents with Systemic Lupus Erythematosus

April 2006 in “ Pediatrics International ”

Kandai Nozu, Kazumoto Iijima, Ichiro Kamioka, Teruo Fujita, Kunihiko Yoshiya, Ryojiro Tanaka, Koichi Nakanishi, Norishige Yoshikawa, Masafumi Matsuo

mizoribine systemic lupus erythematosus steroid dependency hyperuricemia hair loss

TLDR High-dose mizoribine effectively controls symptoms in adolescents with lupus while reducing steroid use, with manageable side effects.

The study investigated the use of high-dose mizoribine (MZR) treatment in five adolescents with systemic lupus erythematosus (SLE), administering 300 mg/day, which is double the conventional adult dose. The treatment aimed to maintain remission and reduce steroid dependency. Results showed that the high-dose MZR was effective in controlling symptoms and allowed for a reduction in steroid dosage. The treatment was generally safe, with hyperuricemia as a noted side effect in two patients, which was managed by dose adjustment or resolved spontaneously. Temporary hair loss exacerbation was observed in two patients but resolved after a few months. The study concluded that high-dose MZR could be effectively and safely used in steroid-dependent pediatric SLE patients, with necessary monitoring of serum uric acid levels.

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