Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling

A study from three years ago found that the Hes1 protein plays a crucial role in regulating hair growth and follicle regeneration in mice by modulating the Hedgehog signaling pathway. Its absence leads to delayed hair growth and reduced follicle regeneration, making it a potential target for hair loss and alopecia treatments. Hes1 enhances Shh signaling during the anagen phase, which helps maintain hair cycle homeostasis. The study suggests that Hes1 could be a potential therapeutic strategy for controlling hair growth and promoting hair follicle regeneration.