Hepatic and Renal Impairment and Degenerative Changes Caused by Carbon Black Nanoparticles in Mice

This study investigated the toxicity of carbon-based nanoparticles (CBNPs) in mice when administered orally over 30 days at doses of 5mg/kg, 10mg/kg, and 20mg/kg. The mice exhibited behavioral changes, alopecia, and physiological alterations in liver and kidney functions, as indicated by changes in enzyme levels and the presence of inflammation and necrotic cells in tissues. The adverse effects were linked to the aggregation of CBNPs, slow clearance, and excessive reactive oxygen species formation, which impair enzyme activities. The study concludes that exposure to CBNPs can disrupt physiological processes, potentially leading to severe and fatal illnesses.