Hair Regrowth in a Patient with Alopecia Universalis and Psoriasis Vulgaris During Deucravacitinib Therapy

    December 2024 in “ JDDG Journal der Deutschen Dermatologischen Gesellschaft ”
    C. Jonas, Michael P. Schön, Rotraut Mößner
    TLDR Deucravacitinib helped a man regrow hair significantly.
    A 51-year-old man with alopecia universalis (AU) and psoriasis vulgaris experienced significant hair regrowth during treatment with deucravacitinib, a tyrosine kinase-2 inhibitor. Initially, the patient had almost complete hair loss and a high Severity of Alopecia Tool Score (SALT score of 97). After 7 months of deucravacitinib therapy, his hair largely regrew, with only a few bald spots remaining, and his SALT score improved to 13. The patient's Dermatology Life Quality Index (DLQI) also improved significantly. This case suggests that deucravacitinib may be effective for AU, warranting further controlled studies to evaluate its impact on alopecia areata.
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