TLDR Keratins are key to developing and regenerating hair follicles for treating hair loss.
The document discussed the role of keratins, a complex protein family, in the regular function of epithelial tissues, including the epidermis and its appendages like hair follicles. It highlighted the importance of keratins in the context of tissue engineering for hair follicles, suggesting that understanding and manipulating these proteins could be crucial for advancements in this field. The study emphasized the potential of keratins to influence the development and regeneration of hair follicles, which could have significant implications for treating hair loss and related conditions.
93 citations
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July 2006 in “Journal of Investigative Dermatology” K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
49 citations
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March 2004 in “Journal of Investigative Dermatology” The hHa7 gene is regulated by androgens in certain body hair, not scalp hair.
132 citations
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February 2002 in “Journal of Biological Chemistry” HOXC13 is crucial for regulating hair keratin genes in hair follicles.
555 citations
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July 2001 in “Genes & Development” Tcf3 and Lef1 are key in deciding skin stem cell roles.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.