Hair Follicle Gene Expression Profiling in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

    December 2025 in “ BMC Medical Genomics ”
    Kristina L. Buschur, Molly Martorella, Renee Garcia-Flores, Benjamin M. Smith, Marcello Ziosi, Igor Barjaktarević, Eugene R. Bleecker, Stephanie A. Christenson, Alejandro P. Comellas, Gerard J. Criner, Mark T. Dransfield, Nadia N. Hansel, Robert J. Kaner, Jerry A. Krishnan, Deborah A. Meyers, Elizabeth C. Oelsner, Victor E. Ortega, Robert Paine, Prescott G. Woodruff, R. Graham Barr, Tuuli Lappalainen
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    Studysummary This study demonstrated that RNA-seq can effectively expand hair follicle transcriptomic profiling in a multi-center study, offering deeper insights than blood transcriptomics alone. Our plain-language summary of this paper — not a Tressless recommendation.
    This study successfully applied RNA sequencing to hair follicle transcriptomic profiling in a multi-center study, demonstrating that it can be scaled up to provide insights not obtainable from blood transcriptomics. This approach offers a novel method for gene expression analysis, potentially enhancing the understanding of various conditions, including COPD, by utilizing hair follicles as a source of genetic information.
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