Dynamic Changes of Gut and Skin Microbiota in Pancreatic Cancer-Induced Skin Injury

This study examines the changes in gut and skin microbiota in mice with pancreatic cancer-induced skin injury, focusing on depilation. Researchers found significant differences in microbial diversity between depilated and non-depilated mice. In depilated mice, there was an increase in Staphylococcus and a decrease in Lactobacillus in the skin microbiota, and reduced diversity in the gut microbiota, suggesting potential damage to the intestinal mucosa. These findings indicate that tumor progression induces distinct microbial changes, potentially contributing to skin disorders like alopecia through the gut-skin axis. The study suggests that these microbial changes could be potential targets for treating cancer-related skin lesions, although it is limited by its use of a murine model.