Effects of Geranium Rose Oil on Keratinocyte Differentiation and Hair Growth

The study investigated the effects of Geranium rose oil on hair growth and keratinocyte differentiation using a shaving animal model of C57BL/6 mice. The mice were divided into three groups: a negative control group (vehicle), a positive control group (5% minoxidil), and an experimental group (3% Geranium rose oil). The oil was applied topically every other day for 4 weeks. Results showed that Geranium rose oil accelerated hair regrowth faster than the vehicle group, promoting hair follicle development and elongation by 115%. Additionally, in vitro tests on human keratinocytes indicated that Geranium rose oil slightly increased involucrin promoter activity, suggesting its potential as a treatment for hair loss and for promoting keratinocyte differentiation.