Genetics of Progeria and Aging

    January 2018 in “ Elsevier eBooks ”
    Sahara Ken, Zhongjun Zhou
    TLDR Progeria, a disease that causes early aging, is linked to a gene mutation and helps us understand normal aging.
    The chapter reviewed Hutchinson–Gilford progeria syndrome (HGPS), a rare and fatal premature aging disease caused by mutations in the LMNA gene, leading to the production of progerin. HGPS presents symptoms similar to physiological aging, such as alopecia, osteoporosis, and cardiovascular diseases, making it a valuable model for studying aging. The chapter covered the genetic and clinical background of HGPS, current therapeutic approaches, mouse models mimicking HGPS features, proposed molecular mechanisms, and the relationship between HGPS and physiological aging.
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