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Did you mean Hutchinson-Gilford Progeria Syndrome?

GlossaryHutchinson-Gilford Progeria Syndrome

rare genetic disorder causing rapid aging in children

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder characterized by rapid aging in children, typically becoming apparent within the first two years of life. It is caused by a mutation in the LMNA gene, which leads to the production of an abnormal protein called progerin, resulting in cellular instability and the accelerated aging process.

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research Epidermal Expression of the Truncated Prelamin A Causing Hutchinson-Gilford Progeria Syndrome: Effects on Keratinocytes, Hair, and Skin

48 citations, April 2008 in “Human Molecular Genetics”

Progerin affects cell shape but not hair or skin in mice.

research Hutchinson-Gilford Progeria Syndrome and Its Relevance to Cardiovascular Diseases and Normal Aging

3 citations, May 2013 in “PubMed”

Research on Hutchinson-Gilford progeria syndrome could help understand normal aging and heart disease.

research Hutchinson-Gilford Progeria Syndrome: Report of 2 Cases and a Novel LMNA Mutation in China

3 citations, September 2013 in “Journal of the American Academy of Dermatology”

A new genetic mutation linked to Hutchinson-Gilford progeria syndrome was found in China.

research Risk Factors, Prevalence, and Diagnosis of Hutchinson-Gilford Syndrome with Special Reference to Case Reports

2 citations, May 2017 in “International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences”

Hutchinson-Gilford Progeria Syndrome is a rare genetic disorder caused by a specific gene mutation, characterized by aging symptoms and managed by monitoring heart health and using low-dose aspirin.

research Intermittent Treatment with Farnesyltransferase Inhibitor and Sulforaphane Improves Cellular Homeostasis in Hutchinson-Gilford Progeria Fibroblasts

32 citations, July 2017 in “Oncotarget”

Alternating treatment with two drugs could help cells in a rapid aging disease.

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