Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in Mouse Plasma

    March 2024 in “ Preprints.org ”
    Shivani Bansal, Yaoxiang Li, Sunil Bansal, William Klotzbier, Baldev Singh, Meth Jayatilake, Vijayalakshmi Sridharan, José A. Fernández, John H. Griffin, Hartmut Weiler, Marjan Boerma, Amrita K. Cheema
    TLDR Activated protein C helps protect mice from radiation damage.
    This study investigates the role of activated protein C (APC) in mitigating delayed effects of acute radiation exposure (DEARE) in mice. Using C57BL/6N wild-type and APCHi transgenic mice exposed to 9.5 Gy γ-rays, researchers found significant dyslipidemia and metabolic dysregulations indicative of inflammatory responses and organ damage. The APCHi mice, however, exhibited near-normal lipid levels and restored plasma metabolites, suggesting APC's protective effects against radiation injuries. The study highlights APC's potential in modulating plasma molecular events post-radiation in a gender-specific manner.
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