Expression of Transforming Growth Factor-β1 and Tumor Necrosis Factor-α in Mice with Radiation-Induced Pulmonary Injury

    January 2010 in “ Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi ”
    Yuan Jun
    TLDR TGF-β1 and TNF-α contribute to lung damage after radiation.
    The study investigated the expression of inflammatory cytokines TGF-β1 and TNF-α in 35 male Balb/c mice subjected to radiation-induced pulmonary injury. Mice were divided into a radiation group and a control group, with observations made on the 15th, 30th, and 90th days post-irradiation. Results showed that the radiation group experienced hair loss, skin rash, and erosion, with extensive collagen deposition observed by the 30th day. The expression of TGF-β1 and TNF-α increased over time after irradiation compared to the control group. The study concluded that the localization of these cytokines in areas of inflammatory cell infiltrates and fibrosis indicated their involvement in the pathogenesis of radiation-induced pulmonary injury.
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