Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in Mouse Plasma

The study examines the impact of genetic upregulation of Activated Protein C (APC) on mitigating delayed effects of acute radiation exposure in mice. Researchers used a sample of 67 mice, including both wild-type and transgenic APCHi mice, exposed to 9.5 Gy of γ-radiation. Six months post-irradiation, plasma metabolic profiles revealed that APC upregulation in APCHi mice normalized several radiation-induced metabolic disturbances, such as lipid and amino acid metabolism, compared to wild-type mice. Gender-specific differences were noted, with distinct metabolic changes in male and female mice. The findings suggest that APC may confer radiation resistance by improving endothelial function and normalizing metabolic pathways, highlighting its potential as a therapeutic agent for managing radiation toxicity. Further research is needed to explore APC's role in long-term radiation toxicity and its therapeutic potential.