Retracted: Explore the Genetic Exposure to Alopecia Areata

July 2024 in “ Skin Research and Technology ”

Shaoyi Peng, Yang Yang, Yilong Man, D. A. Long, Lei Wang, Kaiyuan Li, Peng Liu

alopecia areata Mendelian randomization copper antioxidant serum metabolites transforming growth factor-alpha interleukin-2 receptor subunit beta immune-mediated hair follicle destruction

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

copper →

Studysummary Copper may protect against alopecia areata, while certain inflammatory markers increase risk.

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This retracted study explored the genetic exposure to alopecia areata using Mendelian randomization analysis, involving 64,979 to 460,351 European ancestry participants. It identified an inverse correlation between copper levels and alopecia areata risk, suggesting copper's protective role due to its antioxidant properties. Specific serum metabolites were also inversely correlated, indicating their involvement in metabolic pathways affecting hair health. Conversely, inflammatory markers like transforming growth factor-alpha and interleukin-2 receptor subunit beta were positively correlated with increased risk, highlighting their role in immune-mediated hair follicle destruction. The study calls for further research to clarify these causal mechanisms and address limitations such as genetic tool effectiveness and population representativeness.

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Research cited in this study

8 / 8 results

research Retracted: Explore the Genetic Exposure to Alopecia Areata

2 citations , July 2024 in “Skin Research and Technology”

Copper may protect against alopecia areata, while certain inflammatory markers increase risk.

research Retracted: Causal Role of Immune Cells in Alopecia Areata: A Two-Sample Mendelian Randomization Study

14 citations , January 2024 in “Skin Research and Technology”

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

research Baricitinib for the Treatment of Alopecia Areata

6 citations , May 2023 in “Drugs”

This study reports that baricitinib was more effective than placebo in promoting hair growth in adults with severe alopecia areata after 36 weeks of treatment in clinical trials.

research A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

1 citations , December 2022 in “Bioactive Materials”

In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.

research Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels

11 citations , July 2022 in “Frontiers in immunology”

This study reports that the global age-standardized incidence and disability-adjusted life-year rates of alopecia areata decreased from 1990 to 2019, with the highest increases in incidence seen in some low SDI regions and countries like Kuwait and South Sudan.