A Generalized Reticulate Eruption with Scarring Alopecia, Vulvovaginitis, Keratoderma, and 20-Nail Dystrophy in a 70-Year-Old Woman

    April 2016 in “ Journal of the American Academy of Dermatology ”
    TLDR Treatment improved some symptoms but not all.
    A 70-year-old woman with a history of oral lichen planus (LP) experienced a 2-year progression of symptoms including hairline recession, vulvovaginitis, keratoderma, nail dystrophy, and generalized reticulated hyperpigmentation. Examination showed desquamative gingivitis, white lacy plaques, 20-nail dystrophy, perifollicular erythema, and hairline recession. Histology confirmed LP with a band-like inflammatory infiltrate. Treatment with oral prednisone and methotrexate led to resolution of mucosal lesions and stabilization of hair loss after 2 months, although pruritus and hyperpigmentation persisted.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 421 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community He used Dutasteride for 20 years. Interview

      in Treatment  109 upvotes 1 month ago
      Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

      community Clascoterone (Winlevi) Update for Canada

      in Treatment  17 upvotes 2 years ago
      Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

    Similar Research

    6 / 1000+ results
      Reassessing Frontal Fibrosing Alopecia

      research Reassessing Frontal Fibrosing Alopecia

      1 citations, October 2008 in “Expert Review of Dermatology”
      Frontal Fibrosing Alopecia is a slowly progressing hair loss condition, likely underdiagnosed, with ineffective treatments, needing more research to understand it fully.
      Frontal Fibrosing Alopecia: A Review

      research Frontal Fibrosing Alopecia: A Review

      23 citations, April 2021 in “Journal of Clinical Medicine”
      Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.
      Cicatricial Alopecias

      research Cicatricial Alopecias

      May 2017 in “InTech eBooks”
      Some hair loss disorders cause permanent loss due to scarring, and treatments like steroids don't always work well.