Cutaneous Necrosis After Injection of Polyethylene Glycol–Modified Interferon Alfa
June 2005
in “
Journal of The American Academy of Dermatology
”
cutaneous necrosis pegylated interferon alfa-2b epidermal necrosis acute dermal inflammation tissue eosinophilia focal vasculitis thrombosis small vessel endothelial alterations livedoid necrosis erythema topical care hydrocolloid bandages skin necrosis PEG-interferon skin inflammation skin ulcers blood clots skin redness wound care bandages
Studysummary In this study, pegylated interferon alfa-2b injections led to local cutaneous reactions, including cutaneous necrosis, in patients with hepatitis C and chronic myelocytic leukemia, requiring dose modifications or treatment withdrawal in some cases.
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