Cutaneous Ulcers Due to Interferon Seem Not to Be Related to the Dosage

    September 1999 in “ Journal of the European Academy of Dermatology and Venereology ”
    Annarosa Virgili, Monica Corazza, Anna Rita Lombardi, Laura Sighinolfi
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    TLDR Skin ulcers from interferon may not depend on the amount given.
    The document reported on a 57-year-old man with AIDS-related Kaposi's sarcoma who developed necrotic ulcers at the sites of interferon injections, which did not resolve despite dosage reduction and changing injection sites, and eventually healed with scarring. The patient's death occurred 2 years later due to Kaposi's sarcoma and encephalitis. The authors concluded that the occurrence of cutaneous ulcers from interferon may not be related to the drug's dosage, as ulcers persisted at various dosages. They suggested more frequent changes of injection sites to prevent skin necrosis. The exact cause of the ulceration remains unclear, with several hypotheses mentioned. Additionally, the document touched on the importance of careful donor site care in hair grafting to preserve hair follicles and avoid damage to underlying structures.
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