The Function of 5α-Reductase in Related Diseases
January 2011
in “
Medical Recapitulate
”
TLDR 5α-reductase enzyme affects hormone levels, influencing conditions like acne and hair loss.
The document discussed the role of 5α-reductase, an enzyme crucial for converting testosterone to dihydrotestosterone (DHT), in various diseases. Two isozymes of 5α-reductase, encoded by SRD5A1 and SRD5A2, were identified. Mutations or overexpression of these genes could lead to abnormal androgen levels, contributing to conditions such as acne, androgenetic alopecia, polycystic ovary syndrome, and pseudohermaphroditism. The study of this enzyme was considered significant for understanding these diseases.
