The Protective Role of FTY720 in Promoting Survival of Allograft Fat in Mice

The study on C57BL/6J mice found that FTY720 significantly improved the survival of syngeneic fat allografts by enhancing vascularization, reducing inflammatory cell infiltration, and modulating immune responses. Over 20 weeks, FTY720 increased the presence of Foxp3+ regulatory T cells and altered cytokine expression, boosting anti-inflammatory cytokines IL-4 and IL-10 while decreasing pro-inflammatory cytokines TNF-α and IL-6. These effects led to better fat graft retention and morphology, suggesting FTY720's potential as a drug-assisted strategy for improving allogeneic fat transplantation outcomes. However, further research was needed to explore immune responses and applicability to humans.