Efficacy and Safety of Fractional CO2 Laser Combined with Halometasone Cream for Treatment of Moderate-to-Severe Chronic Hand Eczema: A Prospective, Single-Center, Parallel-Group, Open-Label Randomized Trial

June 2023 in “ Dermatology and Therapy ”

Guangze Tang, Yuan Yen Chang, Haixuan Wu, Xuelei Liang, Yi Liu, Fenglin Zhuo

fractional CO2 laser halometasone cream chronic hand eczema hand eczema severity index dermatology life quality index quality of life in hand eczema questionnaire skin pigmentation CO2 laser HECSI DLQI QOLHEQ

Studysummary This study found that for patients with moderate-to-severe chronic hand eczema, combining fractional CO2 laser with halometasone cream was more effective than using halometasone cream alone, with a higher treatment success rate and fewer relapses, though skin pigmentation was a common side effect.

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A study involving 67 patients with moderate-to-severe chronic hand eczema (CHE) found that the combination of fractional CO2 laser and halometasone cream was more effective than halometasone cream alone. The patients were divided into two groups: group A (33 patients) received the combination treatment, while group B (34 patients) received only the halometasone cream. At week 12, the treatment success rate was 62.1% in group A and 27.6% in group B. The hand eczema severity index (HECSI), dermatology life quality index (DLQI), and quality of life in hand eczema questionnaire (QOLHEQ) all decreased more in group A than in group B, indicating a greater improvement in symptoms and quality of life. The relapse rate at week 24 was lower in group A (11.1%) than in group B (50.0%). The most common adverse effect was skin pigmentation.

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