Increase in Formalin-Induced Tonic Pain by 5α-Reductase and Aromatase Inhibition in Female Rats

    December 2010 in “ Pharmacology Biochemistry and Behavior ”
    Mahnaz Moradi-Azani, Abolhassan Ahmadiani, Hossein Amini
    Studysummary Inhibiting certain enzymes made female rats more sensitive to low-level pain.
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    Research cited in this study 4

    1. 5-Alpha-Reductase 2 Inhibition Impairs Brain Defeminization of Male Rats: Reproductive Aspects Pharmacology Biochemistry and Behavior · 2005
    2. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA A Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004
    3. Selective Non-Steroidal Inhibitors of 5α-Reductase Type 1 Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2004
    4. Increase in Testosterone Metabolism in the Rat Central Nervous System by Formalin-Induced Tonic Pain Pharmacology Biochemistry and Behavior · 2002