Folliculotropic Mycosis Fungoides Following Renal Transplantation
September 2011
in “
Journal of the American Academy of Dermatology
”
folliculotropic mycosis fungoides cutaneous T-cell lymphoma eczema erythema perifollicular pustules furuncles lymphocytic infiltrate follicular mucinosis atypical lymphocytes CD3 CD7 CD5 Epstein-Barr virus clonal T-cell receptor gamma gene post-transplant lymphoproliferative disorder flow cytometry FMF T-cell lymphoma pustules boils lymphocyte infiltration mucinosis EBV PTLD
TLDR A man developed a skin cancer called folliculotropic mycosis fungoides after a kidney transplant.
A 46-year-old Caucasian man developed folliculotropic mycosis fungoides (FMF), a type of cutaneous T-cell lymphoma, two years after a renal transplant. His symptoms included eczematous, erythematous plaques, perifollicular pustules, and furuncles. Histopathology revealed a lymphocytic infiltrate with follicular mucinosis and atypical lymphocytes. Immunophenotyping showed a CD3+ infiltrate with loss of CD7 and intact CD5, and some cells were positive for Epstein-Barr virus (EBV). A clonal T-cell receptor gamma gene pattern confirmed the diagnosis, which was consistent with post-transplant lymphoproliferative disorder (PTLD). Flow cytometry of peripheral blood showed no abnormal population.
