Flutamide

January 2025

Aditya Kumar Bubna

flutamide non-steroidal antiandrogen hirsutism hormonal acne female pattern hair loss

TLDR Flutamide helps with prostate cancer and some skin conditions but can harm the liver.

Flutamide is a non-steroidal antiandrogen approved for advanced prostate cancer treatment and has shown utility in dermatology for conditions like hirsutism, hormonal acne, and female pattern hair loss. Despite its benefits, flutamide's use is limited by its potential to cause liver toxicity, necessitating cautious administration.

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Research cited in this study

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Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

378 citations , November 2011 in “Human reproduction update”

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

research Prospective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss

42 citations , April 2011 in “Annals of Pharmacotherapy”

Flutamide effectively treats female pattern hair loss with low doses showing good liver tolerance.

research ACOG Practice Bulletin No. 108: Polycystic Ovary Syndrome

373 citations , September 2009 in “Obstetrics & Gynecology”

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

research Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

502 citations , February 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Treat significant hirsutism with medication and hair removal; use birth control pills first, adding antiandrogens if needed.

research Treatment of Female Pattern Hair Loss With Oral Antiandrogens

179 citations , March 2005 in “British Journal of Dermatology”

Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.

research Treatment of Hyperandrogenic Alopecia in Women

108 citations , January 2003 in “Fertility and Sterility”

Flutamide may slightly improve hair loss in women, but finasteride does not work.

research A Comparison of the Relative Efficacy of Antiandrogens for the Treatment of Acne in Hyperandrogenic Women

74 citations , August 2002 in “Clinical Endocrinology”

Flutamide and CPA are more effective than finasteride for treating acne in hyperandrogenic women.

research Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial

165 citations , February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.