Flexural Agminated Eruptive Nevi in Langerhans Cell Histiocytosis

    May 2013 in “ JAMA Dermatology ”
    Catherine Surinach, Philippe Bahadoran, P. Vabres, C. Chiavérini, H. Montaudié, N. Erfan, Anne Deville, Candace Ben Signor, Maxime Benchetrit, Thierry Passeron, Jean‐Philippe Lacour
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    TLDR Sunlight exposure improved a patient's skin condition, and there may be a link between a certain disease and skin growths; a leukemia treatment caused changes in hair color and growth.
    The document presents a case study where a patient with dyshidrotic eczema experienced improvement in their condition through daily sunlight exposure, leading to the discontinuation of topical corticosteroids after 205 exposures over several years. The study, supported by the Ministry of Education and Science of the Republic of Serbia, also noted the immunosuppressive effects of UV irradiation, with UV-A1 being more effective than UV-B. Additionally, the document reports on two cases of eruptive nevi in children with Langerhans cell histiocytosis, suggesting a link between the disease and the development of nevi. Furthermore, it describes a case of dasatinib-induced leukotrichia in a patient with chronic myelogenous leukemia, with a scalp biopsy revealing a lack of melanocytes in hair bulbs, indicating that dasatinib's inhibition of kinases may cause changes in hair pigmentation and growth.
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