BH26 First Reported Case of Lichen Planopilaris in Siblings: Evidence for a Genetic Link?

    June 2025 in “ British Journal of Dermatology ”
    E. W. HORTON, Faheem Latheef
    TLDR Lichen planopilaris may have a genetic link.
    This document reports the first known case of lichen planopilaris (LPP) in siblings, suggesting a potential genetic link. The study involves a brother and sister, aged 20 and 24, who developed LPP within a year of each other, exhibiting classic symptoms such as perifollicular erythema and progressive scarring alopecia. A family history of autoimmune diseases, including hypothyroidism and coeliac disease, was noted, but no external triggers were identified. These findings support the hypothesis of a hereditary component in LPP, similar to familial cases of frontal fibrosing alopecia (FFA), and highlight the need for further genetic and immunological research to understand hereditary patterns and improve diagnosis and management.
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