TLDR Finasteride significantly reduced sperm production and caused testicular atrophy in hamsters.
The study investigated the impact of finasteride on spermatogenesis in adult Mesocricetus auratus (hamsters). Twenty hamsters were divided into a control group and an experimental group, each with 10 animals. The experimental group received finasteride subcutaneously for 90 days. Results showed that 40% of the experimental group exhibited hypotrophy of the seminiferous tubules, and 60% had reduced spermatogenesis compared to the control group, which showed no tubular alterations. The difference in testicular alterations between the groups was statistically significant (p=0.043). The study concluded that finasteride administration led to significant tubules atrophy and reduced spermatogenesis in the experimental group.
34 citations
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January 2004 in “Revista do Hospital das Clínicas” Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.
18 citations
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May 2002 in “BJUI” Finasteride doesn't change rat testicle weight or sperm production.
104 citations
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October 1999 in “The Journal of Urology” Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.
1054 citations
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February 1998 in “The New England Journal of Medicine” Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
1040 citations
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October 1992 in “The New England Journal of Medicine” Finasteride effectively treats BPH but may increase sexual dysfunction risk.
211 citations
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November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively treats BPH, but needs more trials to understand potential.
5 citations
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June 2008 in “Acta Cirurgica Brasileira” Finasteride causes sperm production decrease in Mesocricetus auratus.
18 citations
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May 2002 in “BJUI” Finasteride doesn't change rat testicle weight or sperm production.