Finasteride Influence on P-Glycoprotein Functional Activity

December 2012 in “ I P Pavlov Russian Medical Biological Herald ”

E. N. Yakusheva, И. В. Черных

finasteride P-glycoprotein efflux transporter protein pharmacokinetics Propecia

TLDR Finasteride increases P-glycoprotein activity in the liver and kidney.

The study investigated the effect of finasteride on the functional activity of the efflux transporter protein P-glycoprotein (Pgp) in rabbits. By analyzing the pharmacokinetics of the marker substrate fexofenadine, it was determined that a 14-day course of finasteride administration resulted in a tissue-specific increase in Pgp functional activity in the liver and kidney.

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community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

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Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

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