Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

    October 1995 in “ International Journal of Dermatology ”
    Quan Dong Nguyen, Tao Chen, Xuesheng Wang … Paul Chien
    Studysummary This study confirms that finasteride inhibits the conversion of testosterone to dihydrotestosterone in human dermal fibroblasts, suggesting potential therapeutic use for androgen-related skin disorders.
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    Research cited in this study 7

    1. Finasteride: The First 5 Alpha-Reductase Inhibitor PubMed · 1993
    2. Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 1993
    3. Four-Amino Acid Segment in Steroid 5 Alpha-Reductase 1 Confers Sensitivity to Finasteride, a Competitive Inhibitor Journal of Biological Chemistry · 1992
    4. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990
    5. Hair Follicles and Associated Glands as Androgen Targets Clinics in endocrinology and metabolism · 1986
    6. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985
    7. Testosterone Metabolism in the Skin: A Review of Its Function in Androgenetic Alopecia, Acne Vulgaris, and Idiopathic Hirsutism Including Recent Studies with Antiandrogens Archives of Dermatology · 1975

    Related research 6

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    2. Actions of 5α-Reductase Inhibitors on the Epididymis Molecular and Cellular Endocrinology · 2006
    3. Effect of a Novel Steroid (PM-9) on the Inhibition of 5α-Reductase in Penicillium Crustosum Broths Steroids · 2003
    4. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995
    5. Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition The Prostate · 1993
    6. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992