Fibronectin Connecting Cell Sheet Based on Click Chemistry for Wound Repair

The study investigates fibronectin-attached cell sheets (FACS) created via click chemistry for enhanced wound healing. FACS significantly promoted cell migration and proliferation without toxicity, demonstrating high biocompatibility and improved wound repair efficacy in vivo. In experiments with mice, FACS-treated wounds healed faster and more completely than controls, showing higher dermis thickness, reduced inflammation, and increased hair follicle and collagen content. The use of click chemistry improved the stability and bioactivity of the cell sheets, making FACS a promising approach for advanced wound healing therapies.