FGF18 Signaling Determines Radioresistance of Telogen Hair Follicles by the Arrest of Hair Cycling

    September 2016 in “ Journal of dermatological science ”
    Fumiaki Nakayama, Sachiko Umeda, Takashi Yasuda, Mitsuko Kawano, Mayumi Fujita, Atsuko Ishikawa, Toru Imamura, Takashi Imai
    TLDR FGF18 helps hair follicles resist radiation by stopping hair growth cycles.
    The study investigated the role of FGF18 in the radioresistance of telogen hair follicles and its radioprotective effects on radiation-induced hair follicle damage. It was found that telogen hair follicles, when irradiated at 6 Gy, showed hair growth with transient cell growth arrest, while anagen hair follicles did not promote hair growth post-irradiation. Inhibition of FGF receptor signaling in telogen follicles led to cell proliferation but failed to induce hair growth after irradiation. Conversely, recombinant FGF18 induced transient cell growth arrest and enhanced DNA repair after anagen irradiation, resulting in successful hair growth. FGF18 also reduced the expression of cyclin B1 and cdc2, inducing G2/M arrest in keratinocyte cells. These findings suggested that FGF18 signaling contributed to the radioresistance of telogen hair follicles by arresting the cell cycle and highlighted FGF18 as a potential radioprotector against radiation-induced alopecia.
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