Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review

    October 2025 in “ International Journal of Medical Sciences ”
    Sareema Adnan, Manira Maarof, Mh Busra Fauzi, Nur Izzah Md Fadilah
    This comprehensive review highlights the potential of tripeptides in wound healing and skin regeneration, emphasizing their ability to accelerate tissue repair through mechanisms such as cell migration, proliferation, differentiation, and ECM remodeling. Tripeptides like GHK, KdPT, and KPV exhibit antimicrobial and anti-inflammatory properties, enhance fibroblast migration, collagen deposition, and angiogenesis, and combat infections like MRSA. The review also explores the use of tripeptides in nanoparticle conjugates, hydrogels, and clinical derivatives, and discusses their applications beyond wound repair, including cancer and cosmetics. Future research should focus on enhancing the stability, bioavailability, and delivery systems of tripeptides to maximize their clinical potential in regenerative medicine.
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