Exogenous IGF-1 promotes hair growth by stimulating cell proliferation and down regulating TGF-β1 in C57BL/6 mice in vivo

    April 2014 in “ Growth Hormone & IGF Research
    Jingjie Li, Zhihong Yang, Zheng Li, Lijuan Gu, Yunbo Wang, Chang‐Keun Sung
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    TLDR IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.
    The document describes a study where local injections of Insulin-like growth factor 1 (IGF-1) were administered to male C57BL/6 mice, with ten mice in each experimental group. The study demonstrated that IGF-1 increased the number of hair follicles and extended the anagen phase of the hair cycle. It was observed that IGF-1 stimulated cell proliferation within the hair follicle matrix and downregulated Transforming Growth Factor Beta 1 (TGF-β1), which is known to negatively regulate hair growth. These results indicate that IGF-1 could be a potential treatment for hair loss, as it promotes hair growth by enhancing cell proliferation and inhibiting TGF-β1. The research was funded by the National Natural Science Foundation of China under grant number 31070451.
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