Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats

March 2019 in “ International Journal of Endocrinology ”

Chuyan Wu, Feng Jiang, Ke Wei, Feng Lin, Zhongli Jiang

finasteride exercise insulin sensitivity androgen levels ovarian function polycystic ovary syndrome PCOS atresia follicles follicular membrane Propecia

Studysummary In this study, the combination of exercise and finasteride improved ovarian morphology and hormone levels in rats with polycystic ovary syndrome more effectively than either treatment alone.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study investigated the effects of exercise and finasteride, alone and in combination, on hormone and ovarian function in a rat model of polycystic ovary syndrome (PCOS). The results showed that the combined use of finasteride and exercise did not alter the effect of exercise on increasing insulin sensitivity and reducing androgen levels. However, there was a synergistic effect of finasteride and exercise on the morphology of the ovary as the number of atresia follicles and the thickness of the follicular membrane can be reduced. The study suggests that further research is needed to determine the effect of finasteride on the PCOS patient population.

View this study on downloads.hindawi.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research 5α-Reductase Activity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

20 citations , March 2017 in “Reproductive Biology and Endocrinology”

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

research Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study

23 citations , February 2014 in “Journal of Pediatric and Adolescent Gynecology”

This study found that a low-dose intermittent finasteride regimen significantly reduced hirsutism scores in adolescent girls with PCOS or idiopathic hirsutism, with similar efficacy but potentially safer and less expensive than continuous administration.

research Defining Hyperandrogenaemia According to the Free Androgen Index in Chinese Women: A Cross-Sectional Study

19 citations , March 2012 in “Clinical Endocrinology”

This study established a normative free androgen index range of 0.7-6.4 and identified a cut-off value of 6.1 for reproductive-age women in southern China, highlighting hyperandrogenic women's increased metabolic disorder risks.

Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

research Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

1514 citations , December 2011 in “Fertility and sterility”

This consensus report reviews current knowledge and identifies knowledge gaps concerning the various health aspects of polycystic ovary syndrome, without presenting new clinical findings.

research Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats

8 citations , May 2011 in “Journal of Pharmacology and Experimental Therapeutics”

In this study, the safety of finasteride in rats varied depending on dosing time, while its effectiveness on prostate weight reduction remained consistent.

research Effect of Finasteride on Ovulation Induction in Nonresponder (Hyperandrogenic) Polycystic Ovary Syndrome (PCOS) Women

6 citations , April 2009 in “Fertility and Sterility”

Finasteride helps induce ovulation in nonresponder PCOS women.

research Treatment of Hirsutism and Acne in Hyperandrogenism

54 citations , June 2006 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

This review discusses the management of hirsutism and acne in women with polycystic ovary syndrome, highlighting the partial effectiveness of current treatments and suggesting a combined approach of medication and hair removal.

research Effects of Finasteride on the Morphology of Polycystic Ovaries

3 citations , August 2004 in “International journal of gynaecology and obstetrics”

Finasteride doesn't change polycystic ovary size or cyst number, suggesting testosterone's role in their appearance.

research Topical Eflornithine: Efficacy in Reducing Unwanted Facial Hair Growth in Women

115 citations , January 2001 in “American journal of clinical dermatology”

This study found that eflornithine 15% cream reduced unwanted facial hair growth more effectively than a placebo in women with hirsutism, but hair growth returned to pretreatment levels within 8 weeks of stopping treatment.

Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial

research Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial

94 citations , January 2000 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that spironolactone, flutamide, and finasteride are similarly effective in reducing hair diameter and Ferriman-Gallwey scores in women with hirsutism over a 6-month treatment period.

research Usefulness of a 12-Month Treatment with Finasteride in Idiopathic and Polycystic Ovary Syndrome-Associated Hirsutism

4 citations , January 1999 in “PubMed”

research Finasteride in the Treatment of Hirsutism: New Therapeutic Perspectives

50 citations , July 1996 in “Fertility and Sterility”

This study found that finasteride significantly reduced hirsutism scores in women with idiopathic hirsutism and PCOS, despite no changes in serum androgen levels.