Evaluation of the Efficacy and Safety of Topical Sildenafil Citrate Solution in the Treatment of Female Pattern Hair Loss

The study evaluated the efficacy and safety of a 1.0% topical sildenafil citrate solution for treating female pattern hair loss (FPHL) in a randomized controlled trial with 40 participants. Participants were divided into two groups: one treated with the sildenafil solution and the other with a vehicle solution. Results showed that the group treated with sildenafil experienced a significant increase in vellus and terminal hair counts in the frontal and vertex regions, although no change in hair thickness was observed. The study concludes that topical sildenafil 1.0% is a promising treatment for FPHL, recommending further research with larger studies and different concentrations, as well as its combination with other standard therapies like minoxidil and finasteride.