Comparative Study Between the Efficacy and Safety of Topical Sildenafil Citrate Solution and Topical Minoxidil 5% in the Treatment of Female Pattern Hair Loss

    November 2022 in “ Research Square (Research Square) ”
    Heba Abdo Mostafa, Hassan Abou Khodair Mohammed, Ibrahim Fouda
    TLDR Topical minoxidil 5% is better for treating female pattern hair loss than topical sildenafil 1%.
    This exploratory pilot study compared the efficacy and safety of topical sildenafil citrate 1% solution and topical minoxidil 5% foam in treating female pattern hair loss (FPHL) in 30 female patients. Group 1, treated with sildenafil, showed a significant increase in vellus and terminal hair counts in various scalp regions but no significant change in hair thickness. Group 2, treated with minoxidil, exhibited a significant increase in terminal hair count and hair thickness, along with a decrease in vellus hair count in the frontal region. The study concluded that while topical sildenafil 1% is a viable alternative, topical minoxidil 5% remains the preferred treatment for FPHL.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community PP405 - A True Breakthrough or Another Disappointment?

      in Research/Science  33 upvotes 4 months ago
      PP405 shows potential for hair growth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.

      community Why Viagra promotes hair growth like oral minoxidil

      in Minoxidil  84 upvotes 3 years ago
      How oral minoxidil and topical sildenafil (similar to Viagra) are used for hair growth by increasing blood flow to the scalp, and potential side effects of combining these treatments with other drugs.

      community Novel effect of sildenafil (cialis) on hair growth

      in Research/Science  17 upvotes 3 years ago
      Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

      community How to mix Viagra for topical application?

      in Treatment  7 upvotes 2 years ago
      The conversation is about experimenting with topical Viagra or Cialis for hair loss, including methods for dissolving the tablets. The user is also using herbal oil massages and considering using Ethanol/Propylene Glycol for better dissolution.

      community One year off fin/min and I regret it

      in Update  417 upvotes 1 month ago
      The user regrets stopping finasteride and minoxidil due to side effects but plans to resume treatment. They consider using finasteride every other day and continuing topical minoxidil to manage side effects while maintaining hair.

      community What is the ultimate hair regrowth protocol

      in Treatment  29 upvotes 2 months ago
      The conversation covers aggressive hair regrowth treatments like Dutasteride, Minoxidil (oral and topical), RU58841, microneedling, and ketoconazole shampoo. It also mentions PRP, laser therapy, GHK-Cu injections, and hormone therapy for maximum regrowth.

    Related Research

    7 / 7 results