November 2022 in “Research Square (Research Square)” This pilot study observed that topical sildenafil 1% significantly increased vellus and terminal hair counts in female pattern hair loss patients, but did not improve hair thickness, while topical minoxidil 5% increased terminal hair count and thickness, making it the preferred treatment option.
In this study, topical sildenafil citrate was found to improve hair regeneration in a rat model of androgenic alopecia, showing superior long-term effects compared to minoxidil, including increased hair follicle numbers and epidermal thickness.
January 2025 in “International Journal of Medical Arts” This study found that a topical 1.0% sildenafil citrate solution significantly increased vellus and terminal hairs in women with female pattern hair loss without affecting hair thickness, suggesting it may be a promising treatment option.
3 citations
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January 2015 in “Social Science Research Network” This study discusses the role of physicians and pharmaceutical companies as entrepreneurial actors in off-label drug use, arguing they may advance patient care more quickly than regulatory agencies.
16 citations
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October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.