Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells
August 2017
in “Cosmetics”
TLDR The extract reduced sebum production and promoted hair growth.
The study conducted on August 14, 2017, demonstrated that Biota orientalis L. leaf extract (BOLE) and a hair growth plant ethanol extract (HGPEE) containing BOLE could suppress sebum production in cultured sebocytes and promote hair growth. BOLE at concentrations of 25 or 50 µg/mL reduced lipid production in sebocytes, while HGPEE increased mRNA levels of hair growth factors (KGF, VEGF) and enzymes (G3PDH) in human hair papilla cells, as well as mRNA levels of Wnt10b and Lef1 in keratinocytes, which are associated with hair growth. HGPEE also enhanced the proliferation of keratinocytes in co-culture with hair papilla cells. The study, which had sample sizes ranging from n = 3 to n = 4 for various tests, indicated that HGPEE has potential for use in hair loss prevention and hair restoration treatments. Further research is needed to identify the active components responsible for these effects. The research was funded by the Asian Scalp Healthy Research Center in Kobe, Japan.
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