Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques
January 1998
in “Endocrine”
TLDR RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.
The 1998 study investigated the effects of RU58841, a nonsteroidal anti-androgen, on human prostate cancer PC3 cells and its potential as a topical treatment for androgenetic alopecia. The study found that RU58841 had a potency comparable to hydroxyflutamide, a treatment for prostate cancer. Topical application of RU58841 significantly increased hair density, thickness, and length in the Stumptailed Macaques model of androgenetic alopecia, with no systemic side effects detected. The study also noted an increased population and overall size of anagen follicles (active hair growth phase) 5 months after treatment. These results suggested that RU58841 could potentially be an effective topical treatment for androgen-dependent skin disorders, including androgenetic alopecia. However, as the study was conducted on a non-human model, further research would be needed to confirm its effects on humans.
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Cited in this study
research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice
RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque1
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research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism
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Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.
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research Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques
RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.