TLDR Females have higher estrogen receptor levels in hair than males, and these levels decrease in white hair compared to black hair.
The study investigated estrogen receptor levels in black and white hairs of males and females aged 50-56 using a radioreceptor binding assay. It found that females had higher estrogen receptor levels in both black (479.3 ± 37.5 CPM) and white hairs (387.7 ± 33.0 CPM) compared to males, whose black and white hairs had lower receptor levels (316.9 ± 17.8 CPM and 274.0 ± 19.8 CPM, respectively). The results indicated a significant decrease in estrogen receptors in white hairs compared to black hairs for both genders, with the lowest levels recorded in male white hairs. The study concluded that estrogen receptors play a role in hair pigmentation, and their decrease is associated with the transition from black to white hair.
75 citations,
January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
109 citations,
October 2007 in “Journal of pineal research” Melatonin helps regulate hair growth and protects the hair follicle from stress.
159 citations,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
210 citations,
May 2006 in “The FASEB journal” Oxidative stress causes hair to gray by damaging and killing pigment cells.
187 citations,
December 2005 in “Experimental Dermatology” Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.
January 2018 in “Springer eBooks” Gender affects hair and scalp characteristics, with differences in hormone responses, graying patterns, and trace metals.
104 citations,
May 2003 in “Endocrinology” Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.
277 citations,
July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
1 citations,
June 2022 in “Frontiers in Neuroanatomy” Early hormones shape sex-specific differences in rat glands.
30 citations,
June 1988 in “Journal of Steroid Biochemistry” Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.