Erosive Pustular Dermatosis of the Scalp and Multiple Sclerosis: Just a Coincidence?

A 23-year-old woman developed erosive pustular dermatosis of the scalp (EPDS) after mechanical trauma, characterized by an erythematous, crusted patch with partial hair loss and a dermal infiltrate rich in plasma cells and lymphocytes. Histology and clinical findings confirmed EPDS, which improved with topical clobetasol propionate. Subsequently, the patient also developed multiple sclerosis (MS). The study suggests a potential common immunological etiology for EPDS and MS, possibly involving hyperactivation of neutrophils, although the exact pathogenesis of EPDS remains unknown.