Epigenetic Regulation of Macrophage Activity by Glutamine During Wound Healing

This study investigates the role of glutamine metabolism in regulating macrophage activity during wound healing. It reveals that glutaminolysis is crucial for the transition of macrophages from a pro-inflammatory to a pro-resolving state, which is essential for effective tissue repair. The research utilizes integrative metabolomics and transcriptomics, along with dietary and genetic mouse models, to demonstrate that glutaminolysis prevents prolonged inflammation by repressing chromosome accessibility at key inflammatory and migratory genes in macrophages. These findings suggest that targeting glutamine metabolism could offer new therapeutic strategies for controlling inflammation and improving wound healing.