TLDR Erythema multiforme-like lesions can occur in lupus without drug use or herpes infection.
In this case study, a 17-year-old woman with systemic lupus erythematosus (SLE) presented with rare erythema multiforme-like lesions on her hands and feet, alongside symptoms of photosensitivity and hair loss. Histopathological and immunofluorescence examinations confirmed the diagnosis of SLE, revealing hyperkeratosis, parakeratosis, and positive lupus band test, among other findings. Treatment with methylprednisolone led to significant improvement in her symptoms and lesion appearance. This case highlighted that erythema multiforme-like lesions, although uncommon, can occur in systemic lupus erythematosus without a history of drug use or herpes virus infection.
148 citations
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February 2005 in “Autoimmunity Reviews” Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.
132 citations
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July 2000 in “Lupus” In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.
127 citations
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September 1996 in “British Journal of Dermatology” Skin problems are very common in people with systemic lupus erythematosus and important for diagnosis.
157 citations
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August 2010 in “Lupus” The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.
research Skin
2 citations
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January 2011 in “Elsevier eBooks” Skin problems are common in Lupus patients and can indicate the disease's severity, requiring specific treatments and lifestyle changes.
32 citations
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September 1989 in “Medical Clinics of North America” Skin problems are common in lupus, important for diagnosis, and can be triggered by sunlight.
11 citations
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September 2022 in “The Journal of Rheumatology” Skin problems are common in lupus patients and should be treated early to prevent worsening.
January 2012 in “Springer eBooks” Lupus can cause different skin problems, and treatments like quitting smoking and using certain creams or medicines can help.
