Efficacy of Botulinum Toxin in Male Androgenetic Alopecia: A Triple-Blind, Randomized Clinical Trial

July 2024 in “ Journal of the American Academy of Dermatology ”

Daniel Fernandes Melo, Paulo Müller Ramos, Rita Fernanda Cortez de Almeida, Carla Jorge Machado, Sidney Frattini, André Luiz Vairo Donda, Daniela Alves Pereira Antelo, Carlos Baptista Barcauí

botulinum toxin androgenetic alopecia dihydrotestosterone fibroblast activity scalp muscles blood supply Botox AGA DHT

TLDR Botulinum toxin may help treat male pattern baldness.

The study aimed to evaluate the efficacy of botulinum toxin (BT) for treating male androgenetic alopecia (AGA) through a randomized, triple-blind, placebo-controlled clinical trial. The postulated effects of BT include relaxation of scalp muscles, increased blood supply, reduction in tissue dihydrotestosterone levels, and modulation of fibroblast activity. Despite some endorsements in previous literature, no placebo-controlled trial had objectively validated BT for AGA treatment before this study. The results of this trial provide new insights into the potential therapeutic benefits of BT for male AGA.

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Research cited in this study

4 / 4 results

Hair-To-Hair Trichoscopy: An Objective Method To Assess Effectiveness Of Botulinum Toxin In A Clinical Trial For Androgenetic Alopecia

research Hair-To-Hair Trichoscopy: An Objective Method To Assess Effectiveness Of Botulinum Toxin In A Clinical Trial For Androgenetic Alopecia

September 2023 in “Skin appendage disorders”

Trichoscopy, a method of examining hair, can objectively measure how well botulinum toxin works for hair loss treatment.

research Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review

1 citations, September 2021 in “Skin appendage disorders”

Botulinum toxin injections can help treat common hair loss in men, but more research is needed to confirm this and understand how it works.

research Is There a Rationale for the Use of Botulinum Toxin in the Treatment of Androgenetic Alopecia?

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Botulinum toxin may help hair loss by increasing blood flow and reducing harmful factors.

research Therapeutic Effect of Botulinum Toxin on Scalp Alopecia: Physiopathology and Reported Cases - A Systematic Review

13 citations, May 2020 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

Botulinum toxin's effectiveness for treating scalp alopecia is not well-supported due to insufficient data.

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Efficacy of Botulinum Toxin in Male Androgenetic Alopecia: A Triple-Blind, Randomized Clinical Trial

Research cited in this study

research Hair-To-Hair Trichoscopy: An Objective Method To Assess Effectiveness Of Botulinum Toxin In A Clinical Trial For Androgenetic Alopecia

research Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review

research Is There a Rationale for the Use of Botulinum Toxin in the Treatment of Androgenetic Alopecia?

research Therapeutic Effect of Botulinum Toxin on Scalp Alopecia: Physiopathology and Reported Cases - A Systematic Review

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