The Effects of Botulinum Toxin A on Wound and Skin Graft Contraction

    August 2014 in “ Journal of Craniofacial Surgery ”
    Deniz Kucukkaya, Saime İrkören, Selman Ozkan, Nazan Sivrioğlu
    TLDR Botulinum toxin-A reduces wound and skin graft contraction.
    The study investigated the effects of botulinum toxin–A (BTX-A) on wound and skin graft contractions using 30 adult female Wistar rats. The rats were divided into control and experimental groups, with the latter receiving BTX-A injections. Results showed that BTX-A significantly reduced wound and graft contraction. Histological examination revealed increased inflammation and collagen, with altered collagen arrangement in the BTX-A groups. Additionally, BTX-A was effective in reducing the number of sebaceous cells and hair follicles.
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