The Effects of Botulinum Toxin A on Wound and Skin Graft Contraction

August 2014 in “ Journal of Craniofacial Surgery ”

Deniz Kucukkaya, Saime İrkören, Selman Ozkan, Nazan Sivrioğlu

botulinum toxin type A wound contraction skin graft contraction collagen sebaceous cells hair follicles Botox

TLDR Botulinum toxin-A reduces wound and skin graft contraction.

The study investigated the effects of botulinum toxin–A (BTX-A) on wound and skin graft contractions using 30 adult female Wistar rats. The rats were divided into two groups, with one group serving as the control and the other receiving BTX-A injections. Results showed that BTX-A injections reduced the amount of wound and graft contraction. Histological examination revealed higher inflammation and collagen levels, with different collagen arrangements in the BTX-A treated groups. Additionally, BTX-A was found to reduce the number of sebaceous cells and hair follicles.

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The Effects of Botulinum Toxin A on Wound and Skin Graft Contraction

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