EDA2R Is Associated with Androgenetic Alopecia

    September 2008 in “Journal of Investigative Dermatology
    Dionigio Antonio Prodi, Nicola Pirastu, Giuseppe Maninchedda, Alessandro Sassu, Andrea Picciau, Maria Giustina Palmas, A Mossa, Ivana Persico, Mauro F. A. Adamo, Andrea Angius, Mario Pirastu
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    TLDR EDA2R gene linked to hair loss.
    This study aimed to identify genes associated with androgenetic alopecia (AGA) by conducting an epidemiological survey on 9,000 people from 8 isolated villages in Sardinia and genotyping 200 cases and 200 controls. The study found that the EDA2R gene on Xq11-q12 was strongly associated with AGA, while the association with the AR gene seemed to be the result of linkage disequilibrium. The study suggests that the EDA2R gene variation causes susceptibility to AGA, while markers on the AR gene could be associated because of LD. Further functional and genetic studies are needed to clarify the role of these two genes and their possible interactions in the etiology of AGA.
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